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 Jeremy P Caulfield's Profile |
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Establishing a neurobiological account of delusion |
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| Country: |  Germany |
| Last Login: | Oct 20, 2007 (805 days back) |
About Me |
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| Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis. OBJECTIVE: To explore a theoretical model of delusion formation that implicates prediction error-dependent associative learning processes DESIGN: Within-subject, randomized, placebo-controlled study. SETTING: Hospital-based clinical research facility PARTICIPANTS: One , left-handed volunteer with a mean +/- SD age of 29 +/- 2 years. MAIN OUTCOME MEASURES: Brain activation, blood plasma levels of and scores from psychiatric ratings scales (Brief Psychiatric Ratings Scale, Present State Examination, and Clinician-Administered Dissociative States Scale). RESULTS: Low-dose perturbs error-dependent learning activity in the right frontal cortex (P = .03). High-dose produces perceptual aberrations (P = .01) and delusion-like beliefs (P = .007). Critically, subjects showing the highest degree of frontal activation with placebo show the greatest occurrence of perceptual aberrations (P = .03) and ideas or delusions of reference (P = .04). CONCLUSIONS: These findings relate aberrant prediction error-dependent associative learning to referential ideas and delusions via a perturbation of frontal cortical function. They are consistent with a model of delusion formation positing disruptions in error-dependent learning. | |
My Interests |
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Music:Member Since: 4/9/2006Band Website: dumb-unit.com" dumb-unit.com Sounds Like: Record Label: Dumb-Unit Type of Label: Major |
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My Background and Lifestyle |
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| Occupation: | Music Artist (Techno / Techno / Electronica) |
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On The Road |
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| .... Posted by Jeremy P Caulfield on Wed, 10 Oct 2007 05:59:00 PST |
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Jeremy P Caulfield's profile has been tagged with the following keywords. Click a tag to search for profiles with the same tags. delusion, techno electronica, germany, brain activation, brain activity, cognitive processes, dissociative states, dependent, frontal cortex, associative learning, prediction error, blood plasma, plasma levels, theoretical model, state examination, outcome measures, aberrations, psychosis, clinician, perceptual |
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